The Sullivan Lab, MCD Biology, UCSC  



Sullivan Lab Publications

Karg, T, Elting, MW, Vicars, H, Dumont, S, Sullivan,W (2017) The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregationin. Journal Cell Biology (in press).

Sullivan W, O'Neill SL, Microbiology: Manipulation of the manipulators (2017). Nature 543(7644):182-183 [PDF]

Brose L, Crest J, Tao L, Sullivan W (2017). Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector.  Mol Biol Cell. 2017  [Epub ahead of print]

White, PM, Serbus, LR, Debec, A, Codina, A, Bray, W, Guichet, A, Lokey, S, Sullivan, W (2017) Reliance of Wolbachia on High Rates of Host Proteolysis Revealed by a Genome-Wide RNAi Screen of Drosophila Cells. Genetics 205(4):1473-1488 [PDF]

White PM, Pietri JE, Debec A, Russell S, Patel B, Sullivan W (2017) Mechanisms of horizontal cell-to-cell transfer of Wolbachia spp. in Drosophila melanogaster. Appl Environ Microbiol 17;83(7) [PDF]

Sullivan, W (2016) Endosymbiosis: The Remarkable Healing Powers of Wolbachia. Current Biology 26: R797-9 [PDF]
Van Voorhis WC, Adams JH, Adelfio R, and 198 others including White P and Sullivan W (2016) Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.  PLoS Pathog. 12(7):e1005763 [PDF]

Pietri JE, DeBruhl H, Sullivan, W (2016) The rich somatic life of Wolbachia. Microbiology Open. doi: 10.1002/mbo3.390 [PDF]

Tao, L, Fasulo, B, Warecki, B,William Sullivan, W (2016) Tum/RacGAP functions as a switch activating the Pav/kinesin-6 motor. Nature Communications 19;7:11182 [PDF]

Sullivan, W (2016)  The untapped cell biology of neglected tropical diseases. Mol Biol. Cell 27(5):739-43. doi: 10.1091/mbc. e15-11-0771 [PDF]

DeBruhl, H, Albertson R, Swider Z, Sullivan W (2015) Rop, the Sec1/Munc18 homolog in Drosophila, is required for furrow ingression and stable cell shape during cytokinesis. J Cell Sci 15;129(2):430-43 [PDF]

Karg T, Warecki B, and Sullivan W (2015) Aurora B mediated localized delays in nuclear envelope formation facilitates inclusion of late segregating chromosome fragments. MBoC 26(12):2227-41 [PDF]

Serbus L, White P, Pintado Silva J, Rabe A, Teixeira L, Albertson R, Sullivan W (2015) The impact of host diet on Wolbachia titer in Drosophila. PLoS Pathogens 11(3):e1004777 [PDF]

Sullivan, W (2014) The institute for non-model organisms and other fantasies. Mol Biol Cell. 2015 Feb 1;26(3):387-9. [PDF]

Tirmarche S, Kimura S, Sapey-Triomphe L, Sullivan W, Landmann F, Loppin B (2014) Drosophila protamine-like Mst35Ba and Mst35Bb are dispensable for male fertility. Genes, Genomes and Genomics: 4(11):2241-5. [PDF]

Oliveira R A, Kotadia S , Mirkovic M, Bowlin K, Eichinger CS, Nasmyth K, Sullivan W (2014) Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase. PLOS Biology 12(10):e1001962. [PDF]

Landmann F, Foster J.M, Michalski S, Slatko BE, Sullivan W (2014) Co-evolution between an endosymbiont and its nematode host: Wolbachia asymmetric posterior localization and AP polarity establishment. PLOS Negl Trop Dis Aug; 8(8): e3096. [PDF]

Fasulo B, Sullivan W (2014) Live confocal analysis of mutant- and drug-treated Drosophila embryos. Methods Mol Biol. 2014;1075:243-55. [PDF]

Albertson RJ, Tan V, Leads RR, Reyes M, Sullivan W, Casper-Lindley C (2013) Mapping Wolbachia distributions in the adult Drosophila brain. Cell Microbiol. [PDF]

Martins T, Kotadia, S, Malmanche, N, Sunkel, CE, and Sullivan, W (2012) Strategies for outcrossing and genetic manipulation of Drosophila compound autosome stocks G3:Genes Genomes Genetics. (1):1-4. [PDF]

Kotadia S*, Montembault E*, Sullivan W, Royou A. (2012) Cell elongation – an adaptive response clearing long chromatid arms from the cleavage plane. Journal of Cell Biology 199(5):745-53. [PDF]

Serbus LR*, Landmann F*, Bray WM, White PM, Ruybal J, Lokey RS, Debec A, Sullivan W. (2012) A Cell-Based Screen Reveals that the Albendazole Metabolite, Albendazole Sulfone, Targets Wolbachia. PLoS Pathog. Sep;8(9):e1002922. [PDF]

Tao X, Crest J, Kotadia S, Azucena O, Chen DC, Sullivan W, Kubby J. (2012) Live imaging using adaptive optics with fluorescent protein guide-stars. Opt Express. 20(14):15969-82.

Crest J, Concha-Moore K, and Sullivan W. (2012) RhoGEF and positioning Rappaport like furrows in the early Drosophila embryo. Curr Biol. 2012 Sep 25. [PDF]

Landmann F, Bain O, Martin C, Uni S, Taylor MJ, Sullivan W. (2012) Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes. Biology Open 000, 1-12. [PDF]

Landmann F*, Foster JM*, Slatko BE and Sullivan W (2012) Efficient in vitro RNA interference and immunofluorescence-based phenotype analysis in a human parasitic nematode, Brugia malayi. Parasites & Vectors 5:16 (13 January 2012). [PDF]

Fasulo B*,Koyama C*,Yu KR*,Homola EM, Hsieh TS, Campbell SD and Sullivan W (2011) Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation and anaphase entry. Molecular Biology of the Cell 23 (6): 1047-57. [PDF]

Azucena O, Crest J, Kotadia S, Sullivan W, Tao X, Reinig M, Gavel D, Olivier S, Kubby J. (2011) Adaptive optics wide-field microscopy using direct wavefront sensing. Opt Lett. 36(6):825-7. [PDF]

Crest J, Kotadia S, Sullivan W. (2011) Telescopes, Stars and Cells: Adaptive Optics Microscopy. SPIE (Society of Photo-Optical Instrumentation Engineers) Newsletter DOI: 10.1117/2.1201110.003901. [PDF]

Landmann F, Voronin D, Sullivan W, Taylor MJ. (2011) Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes. PLoS Pathog 7(11): e1002351. [PDF]

Serbus LR, Ferreccio A, Zhukova M, McMorris C, Kiseleva E, Sullivan W. (2011) A feedback loop bewteen Wolbachia and the Drosophila gurken nRNP complex influences Wolbachia titer. J Cell Sci 2011 Dec 15;124:4299-308. [PDF]

Casper-Lindley C, Kimura S, Saxton DS, Essaw Y, Simpson I, Tan V, Sullivan W. (2011) Fluorescent-based method for rapid Wolbachia detection in the Drosophila germline and somatic tissues. Appl Environ Microbiol. 17 (44): 4788-4794. [PDF]

Kotadia S, Crest J, Tram U, Riggs B, Sullivan W. (2010) Blastoderm Formation and Cellularisation in Drosophila melanogaster. In: Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester [PDF]

Ferri E, Bain O, Barbuto M, Martin C, Lo N, Uni S, Landmann F, Baccei SG, Guerrero R, de Souza Lima S, Bandi C, Wanji S, Diagne M, Casiraghi M. (2011) New insights into the evolution of Wolbachia infections in filarial nematodes inferred from a large range of screened species. PLoS One. 2011;6(6): e20843. [PDF]

Azucena O, Crest J, Cao J, Sullivan W, Kner P, Gavel D, Dillon D, Olivier S, Kubby J. (2010) Wavefront aberration measurements and corrections through thick tissue using fluorescent microsphere reference beacons. Opt Express 18(16):17521-32. [PDF]

Landmann F, Foster JM, Slatko B, Sullivan W. (2010) Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues. PLoS Negl Trop Dis. 27;4(7):e758. [PDF]

Cao J, Crest J, Fasulo B, Sullivan W. (2010) Cortical actin dynamics facilitates early stage centrosome separation. Current Biology 20 (8): 770-776. [PDF]

Royou A, Gagou ME, Karess R , Sullivan W. (2010) BubR1- and Polo-Coated DNA Tethers Facilitate Poleward Segregation of Acentric Chromatids. Cell 140, 235–245. [PDF]

Debec A, Sullivan W, Bettencourt-Dias M (2010) Centrioles: active players or passengers during mitosis? Cell Mol Life Sci 67 (13): 2173-94. [PDF]

Albertson R*, Casper-Lindley C*, Cao J, Tram U, Sullivan W (2009) Symmetric and asymmetric mitotic segregation patterns determine Wolbachia distribution in somatic host tissue. J Cell Sci. 122, 4570-4583. [PDF]

Sullivan W. (2009) Centrosomes: CNN's broadcast reaches the cleavage furrow. Curr Biol. 2009 Jul 14;19(13): 513-5. [PDF]

Asucena O, Kubby J, Crest J, Cao J, Sullivan W, Kner P, Gavel D, Dillon D, Olivier S. (2009) Implementation of a Shack-Hartmann wavefront sensor for the measurement of embryo-induced aberrations using fluorescent microscopy Proc. SPIE, Vol. 7209, 720906.

Landmann F, Orsi GA, Loppin B, Sullivan W. (2009) Wolbachia-mediated cytoplasmic incompatibility is associated with impaired histone deposition in the male pronucleus. PLoS Pathog. 2009 Mar;5(3):e1000343. [PDF]

Royou A, McCusker D, Kellogg DR, Sullivan W. (2008) Grapes(Chk1) prevents nuclear CDK1 activation by delaying cyclin B nuclear accumulation. J Cell Biol. 2008 Oct 6;183(1):63-75. [PDF]

Clark ME, Bailey-Jourdain C, Ferree PM, England SJ, Sullivan W, Windsor DM, Werren JH. (2008) Wolbachia modification of sperm does not always require residence within developing sperm. Heredity 101(5): 420-8. [PDF]

Serbus LR, Casper-Lindley C, Landmann F, Sullivan W. (2008) The genetics and cell biology of Wolbachia-host interactions. Annu. Rev. Genet 42: 683–707. [PDF]

Cao J, Albertson R, Riggs B, Field CM, Sullivan W. (2008) Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization. J. Cell Biol 182(2): 301-13. [PDF]

Albertson R, Cao J, Hsieh TS, Sullivan W. (2008) Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle. J Cell Biol. 181(5):777-90. [PDF]

Serbus LR, Sullivan W. (2007) A cellular basis for Wolbachia recruitment to the host germline. PLoS pathogens 3 (12): 1930-1937. [PDF]

Riggs B, Fasulo B, Royou A, Mische S, Cao J, Hays TS, Sullivan W. (2007) The Concentration of Nuf, a Rab11 Effector, at the
Microtubule-organizing Center Is Cell Cycle-regulated, Dynein-dependent, and Coincides with Furrow Formation. Mol Biol Cell 18: 3313-3322. [PDF]

Tram U, Fredrick K, Werren JH, Sullivan W. (2006) Paternal chromosome segregation during the first mitotic division determines Wolbachia-induced cytoplasmic incompatibility phenotype. J Cell Sci. 119: 3655-63. [PDF]

Ferree PM, Sullivan W. (2006) A Genetic Test of the Role of the Maternal Pronucleus in Wolbachia-Induced Cytoplasmic Incompatibility in Drosophila melanogaster. Genetics 173(2): 839-47. [PDF]

Ferree PM, McDonald K, Fasulo B, Sullivan WT. (2006) The origin of Centrosomes in Parthenogenetic Hymenopteran Insects. Current Biol. 16: 801-807. [PDF]

Albertson R, Riggs B, and Sullivan W. (2005) Membrane traffic: a driving force in cytokinesis. Trends Cell Biol 15: 92-101. [PDF]

Royou A, Macias H, and Sullivan, W. (2005) The Drosophila Grp/Chk1 DNA damage checkpoint controls entry into anaphase. Curr Biol, 15: 334-339. [PDF]

Field C.M., Coughlin M., Doberstein S, Marty T, Sullivan W. (2005) Characterization of scraps mutants reveals an essential role for anillin in septing localization and cortex/plasma membrane integrity. Development 132: 2849-2860. [PDF]

Kidd, T., R. Abu-Shumays, A.Katzen, J. Sisson, G.Jimenez, S. Pinchin, W. Sullivan, D. Ish-Horowicz. (2005) The epsilon subunit of mitochondrial ATP synthase is required for normal spindle orientation during the Drosophila embryonic divisions. Genetics 170: 697-708. [PDF]

Ferree, P.M., H.M. Frydman, J.M. Li, J. Cao, E. Wieschaus, W. Sullivan. (2005) Wolbachia utilize host microtubules and dynein for anterior localization in the Drosophila oocyte. PLoS Pathogens 2: 0111-0124. [PDF]

Royou, A., C. Field, J. Sisson, W. Sullivan and R. Karess (2004). Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos. Mol Biol Cell, 15: 838-850. [PDF]

Tram, U., P. Ferree, and W. Sullivan. (2003) Identification of Wolbachia-host interacting factors through cytological analysis. Microbes Infect 5(11): 999-1011. [PDF]

Riggs, B., W. Rothwell, S. Mische, G.R.X. Hickson, G.W. Gould, T. Hays, and W. Sullivan. (2003) Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11. Journal of Cell Biology, 163: 143-154. [PDF]

Hickson G.R.X., J. Matheson, B. Riggs, V.H. Maier, A.B. Fielding, R. Prekeris, W. Sullivan, F.A. Barr, and G.W. Gould. (2003) Arfophilins are dual arf/rab11 binding proteins that regulate recycling endosome distribution and are related to Drosophila Nuclear-fallout. Molecular Biology of the Cell, 14: 2908-20. [PDF]

Royou, A., W. Sullivan and R. Karess (2002). Cortical recruitment of nonmuscle myosin II in early syncytial Drosophila embryos: its role in nuclear axial expansion and its regulation by Cdc2 activity. Journal of Cell Biology, 158:127-137. [PDF]

Tram, U., and W. Sullivan (2002) Role of delayed nuclear envelope breakdown and mitosis in Wolbachia-induced cytoplasmic incompatibility. Science. 296: 1124-1126. [PDF] Tram, U., B. Riggs, and W. Sullivan (2001). Cleavage and gastrulation in Drosophila embryos. Encyclopedia of Life Sciences. Macmillan Reference Ltd. In Encyclopedia of Life Sciences. Nature Publishing Group. London. [PDF]

Debec, A., M. Grammont, G. Berson, B. Dastugue, W. Sullivan, J.L. Couderc. (2001) Toucan protein is essential for the assembly of syncytial mitotic spindles in Drosophila melanogaster. Genesis. 31: 167-175. [PDF]

Tram, U., B. Riggs, C. Koyama, A. Debec, and W. Sullivan (2001). Methods for the study of centrosomes in Drosophila during embryogenesis. In Methods in Cell Biology: Centrosomes and Spindle Pole Bodies. R.E. Palazzo and T.N. Davis, Editors. Academic Press. San Diego. 67: 113-123.

Tram, U. and W. Sullivan (2001). Live confocal analysis of fertilization and early development. Microscopy and Microanalysis 7, 1012-1013. [PDF]

MacDougall, N., Y. Lad, G.S. Wilke, H. Francis-Lang, W. Sullivan, and I. Davis (2001). Merlin, the Drosophila homologue of neurofibromin 2, is specifically required in posterior follicle cells for axis formation in the oocyte. Development 128, 665-673. [PDF]

Sisson, J.C., C. Field, R. Ventura, A. Royou, and W. Sullivan. (2000) Lava Lamp, a Novel Peripheral Golgi Protein, Is Required for Drosophila melanogaster Cellularization. J. Cell Biol.151:905-918. [PDF]

Morris, R.L., H.L. Brown, B.D. Wright, D.J. Sharp, W. Sullivan, and J.M. Scholey. (2001) Microinjection methods for analyzing the functions of kinesins in early embryos. Methods in Molecular Biology 164: 163-172.

Tram, U. and W. Sullivan. (2000) Reciprocal inheritance of centrosomes in the parthenogenetic Hymenopteran Nasonia vitripennis. Current Biology10:1413-1419. [PDF]

Yu K. R., R. Saint, and W. Sullivan. (2000) The Grapes checkpoint coordinates nuclear envelope breakdown and chromosome condensation. Nature Cell Biology2:609-615. [PDF]

Rothwell, W.F. and W. Sullivan. (2000) The centrosome in early Drosophila embryogenesis. Current Topics Developmental Biology 49:409-447.

Zhang C. X., W.F. Rothwell, W. Sullivan and T. Hsieh. (2000) Discontinuous actin hexagon, a protein essential for cortical furrow formation in Drosophila is membrane associated and hyper-phosphorylated. Molecular Biology of the Cell11:1011-1022. [PDF]

Sisson, J.C., W.F. Rothwell, and W. Sullivan. (1999) Cytokinesis: Lessons from Rappaport and the Drosophila blastoderm embryo. Current Biology International 23:871-876.

Rothwell, W.F., C.X. Zhang, C. Zelano, T. Hsieh, And W. Sullivan. (1999) The Drosophila centrosomal protein Nuf is required for recruiting Dah, a membrane associated protein, to furrows in the early embryo. Journal of Cell Science 112:2885-2893. [PDF]

Sharp, D.J, K. R. Yu, J. C. Sisson, W. Sullivan, J. M. Scholey. (1999) The antagonistic microtubule sliding motors, KLP61F and Ncd, determine the relative position of mitotic centrosomes in Drosophila embryos. Nature Cell Biology 1:51-54. [PDF]

Rothwell, W.F. and W. Sullivan. (1999) Fluorescent analysis of Drosophila embryos In Drosophila Protocols Editors: Sullivan, W., M. Ashburner, R.S. Hawley. Cold Spring Harbor Laboratory Press. [PDF]

de Saint Phalle, B. and W. Sullivan. (1998) Spindle assembly and mitosis without centrosomes in parthenogenic Sciara embryos. Journal of Cell Biology 141:1383- 1391. [PDF]

Rothwell, W.F. , P. Fogarty, C.M. Field, and W. Sullivan.(1998) Nuclear-fallout, a Drosophila protein that cycles from the cytoplasm to the centrosomes, regulates cortical microfilament organization. Development 125 (7):1295-130. [PDF]

Francis-Lang, H. , J. Minden , W. Sullivan, and K. Oegema. (1998) Live confocal analysis with fluorescently labeled proteins. In: Methods in Molecular biology, vol. 122: Confocal Microscopy Methods and Protocols. 223-239. Edited by S. Paddock. Humana Press, Inc., Totowna, NJ.

Yu, K. R., R.J. Duronio, and W. Sullivan. (1998) Cell cycle checkpoints: safe passage through mitosis In Mechanisms of Cell Division: Frontiers in Biology. Oxford University Press. [PDF]

Cunniff, J., J. Blethrow, and W. Sullivan. (1998) Live analysis of the division cycles in X-irradiated Drosophila embryos. Methods in Molecular Biology Vol 113: DNA Repair Protocols: Eukaryotic Systems. Edited D.S. Henderson. Humana Press Inc.,Totowa, NJ.

Fogarty, P. , S.D. Campbell , R. Abu-Shumays , B. de Saint Phalle , K.R. Yu , G.L. Uy , M.L. Goldberg, and W. Sullivan. (1997) The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity. Current Biology 7:418-426. [PDF]

de Saint Phalle, B., and W. Sullivan. (1996) Incomplete sister chromatid separation is the mechanism of programmed chromosome elimination during early Sciara coprophila embryogenesis. Development 122:3775-3784. [PDF]

Dernberg, A.F., D.R. Daily, K.J. Yook , J.A. Corbin , J.W. Sedat, and W. Sullivan. (1996) Selective loss of compound-chromosome bearing sperm in the Drosophila Female. Genetics 143:1629-1642. [PDF]

Debec, A. , R.F. Kaplin, D.R. Daily, P.D. McCallum, W.F. Rothwell, and W. Sullivan. (1996) Live analysis of free centrosome behavior in normal and aphidicolin-treated Drosophila embryos. J. Cell Biol. 134:103-115. [PDF]

Sullivan, W. and W. Theurkauf. (1995). The cytoskeleton and morphogenesis of the early Drosophilia embryo. Current Opinion in Cell Biology 7:18-22.

Fogarty, P. , R.F. Kalpin, and W. Sullivan. (1994) The Drosophila maternal-effect mutation grapes causes a metaphase arrest at nuclear cycle 13. Development 120: 2131-2141. 1, #3, p. 3 (unreviewed). [PDF]

Kalpin, R.F., D.R. Daily, and W. Sullivan. (1994) Use of dextran beads for live analysis of the nuclear division and nuclear envelope breakdown/reformation cycles in the Drosophila embryo. BioTechniques 17: 730-733.

Sullivan, W., D.R. Daily, P. Fogarty, K. Yook, and S. Pimpinelli. (1993) Delays in anaphase initiation occur in individual nuclei of the syncytial Drosophila embryo. Molecular Biology of the Cell 4:885-896. [PDF]

Sullivan, W. (1993) The Salvation of Doug. Generations (Genetics Society of America) Vol. 1, Number 3, p. 3. (unreviewed). [PDF]

Sullivan, W., P. Fogarty, and W. Theurkauf. (1993) Mutations affecting the cytoskeletal organization of syncytial Drosophila embryos. Development 118:1245-1254. [PDF]

Kellogg, D.R., W. Sullivan, W. Theurkauf, K. Oegema, J.W. Raff, and B.M. Alberts. (1991) Studies on the centrosome and cytoplasmic organization in the early Drosophila embryo. Cold Spring Harbor Symposia on Quantitative Biology Vol. LVI: 649-662. [PDF]

Sullivan, W., J. Minden, and B.M. Alberts. (1990) daughterless abo-like (dal), a Drosophila maternal-effect mutation that exhibits abnormal centrosome separation during the late blastoderm divisions. Development 110:311-323. [PDF]

Sullivan, W. (1987) Independence of fushi tarazu expression with respect to cellular density in Drosophila embryos. Nature 327: 164-167.

Pimpinelli, S., W. Sullivan, M. Prout, and L. Sandler. (1985) On biological functions mapping to the Heterochromatin of Drosophila melanogaster. Genetics 109: 701-724.

Sullivan, W. and S. Pimpinelli. (1986) The genetic factors altered in homozygous abo stocks of Drosophila melanogaster. Genetics114:885-895.

Books and Chapters.

Barbara Fasulo, William Sullivan (2008) Live Confocal Analysis of Mutant- and Drug-Treated Drosophila Embryos. Book Title: Confocal Microscopy: Methods and Protocols. Series: Methods in Molecular Biology, Volume: 1075: 243-255. Springer Science+Business Media.

Sullivan, W., M. Ashburner, R.S. Hawley (Editors) (2000). Drosophila Protocols. Cold Spring Harbor Laboratory Press.

Site design: David States. Comments or corrections. Last reviewed 4/12/15